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RNA m6A modification and its function in diseases
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《医学前沿(英文)》 2018年 第12卷 第4期 页码 481-489 doi: 10.1007/s11684-018-0654-8
N6-methyladenosine (m6A) is the most common post-transcriptional RNA modification throughout the transcriptome, affecting fundamental aspects of RNA metabolism. m6A modification could be installed by m6A “writers” composed of core catalytic components (METTL3/METTL14/WTAP) and newly defined regulators and removed by m6A “erasers” (FTO and ALKBH5). The function of m6A is executed by m6A “readers” that bind to m6A directly (YTH domain-containing proteins, eIF3 and IGF2BPs) or indirectly (HNRNPA2B1). In the past few years, advances in m6A modulators (“writers,” “erasers,” and “readers”) have remarkably renewed our understanding of the function and regulation of m6A in different cells under normal or disease conditions. However, the mechanism and the regulatory network of m6A are still largely unknown. Moreover, investigations of the m6A physiological roles in human diseases are limited. In this review, we summarize the recent advances in m6A research and highlight the functional relevance and importance of m6A modification in in vitro cell lines, in physiological contexts, and in cancers.
Ribozyme and the mechanisms that underlie RNA catalysis
Timothy J. Wilson,Yijin Liu,David M. J. Lilley
《化学科学与工程前沿(英文)》 2016年 第10卷 第2期 页码 178-185 doi: 10.1007/s11705-016-1558-2
基于RNA的生物防治——一种作物保护新模式 Review
Matthew Bramlett, Geert Plaetinck, Peter Maienfisch
《工程(英文)》 2020年 第6卷 第5期 页码 522-527 doi: 10.1016/j.eng.2019.09.008
关键词: 基于RNA的生物防治 RNA干扰(RNAi) 科罗拉多马铃薯甲虫(CPB) 玉米根虫(CRW) 大豆臭虫(SSB)
Blockage of receptor-interacting protein 2 expression by small interfering RNA in murine macrophages
LIU Hongchun, CAO Zhongwei, JIN Jianjun, WANG Jiyao
《医学前沿(英文)》 2008年 第2卷 第2期 页码 166-170 doi: 10.1007/s11684-008-0030-1
Xuefei Ma, Wei Zhang, Rong Zhang, Jingming Li, Shufen Li, Yunlin Ma, Wen Jin, Kankan Wang
《医学前沿(英文)》 2019年 第13卷 第3期 页码 330-343 doi: 10.1007/s11684-017-0557-0
Sustainable functionalization and modification of materials via multicomponent reactions in water
《化学科学与工程前沿(英文)》 2022年 第16卷 第9期 页码 1318-1344 doi: 10.1007/s11705-022-2150-6
关键词: materials multicomponent reactions modification functionalization water
An investigation on modification mechanism of CH
Qiang XIN, Shanghong HUANG
《结构与土木工程前沿(英文)》 2017年 第11卷 第3期 页码 293-300 doi: 10.1007/s11709-017-0403-0
关键词: low temperature coal tar pitch modification road performance
《化学科学与工程前沿(英文)》 2023年 第17卷 第8期 页码 991-1009 doi: 10.1007/s11705-022-2259-7
关键词: low dielectric constant chemical and physical modification cellulose insulating paper transformer nanomaterials.
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《医学前沿(英文)》 2017年 第11卷 第4期 页码 502-508 doi: 10.1007/s11684-017-0590-z
Although the efficacy of nucleos(t)ide analogue (NA) has been confirmed for treatment of chronic hepatitis B, long-term therapy has been recommended due to the high frequency of off-therapy viral DNA rebound and disease relapse. In this review, the RNA virion-like particles of hepatitis B virus (HBV) are integrated into the life cycle of HBV replication, and the potential significance of serum HBV RNA is systematically described. The production of HBV RNA virion-like particles should not be blocked by NA; in this regard, serum HBV RNA is found to be a suitable surrogate marker for the activity of intrahepatic covalently closed circular DNA (cccDNA), particularly among patients receiving NA therapy. Therefore, the concept of virological response is redefined as persistent loss of serum HBV DNA and HBV RNA. In contrast to hepatitis B surface antigen (HBsAg) that can originate from either the cccDNA or the integrated HBV DNA fragment, serum HBV RNA, with pregenomic RNA origination, can only be transcribed from cccDNA. Therefore, the loss of serum HBV RNA would likely be a promising predicator for safe drug discontinuation. The clinical status of consistent loss of serum HBV RNA accompanied with low serum HBsAg levels might be implicated as a “para-functional cure,” a status nearly close to the functional cure of chronic hepatitis B, to distinguish the “functional cure” characterized as serum HBsAg loss with or without anti-HBs seroconversion.
关键词: chronic hepatitis B serum HBV RNA nucleos(t)ide analogs virological response para-functional cure
《医学前沿(英文)》 doi: 10.1007/s11684-023-1017-7
关键词: single-cell RNA-seq glioma radial glia primitive oligodendrocyte precursor cell immune escape
Construction and identification of lentiviral RNA interference vector of rat leptin receptor gene
Zhengjuan LIU, Jie BIAN, Yuchuan WANG, Yongli ZHAO, Dong YAN, Xiaoxia WANG
《医学前沿(英文)》 2009年 第3卷 第1期 页码 57-60 doi: 10.1007/s11684-009-0003-z
Crystal modification of rifapentine using different solvents
Kun ZHOU, Jun LI, Jianhong LUO, Dongsheng ZHENG,
《化学科学与工程前沿(英文)》 2010年 第4卷 第1期 页码 65-69 doi: 10.1007/s11705-009-0302-6
关键词: identical scanning calorimetry different comparative dissolution structure modification
《化学科学与工程前沿(英文)》 2023年 第17卷 第12期 页码 1837-1865 doi: 10.1007/s11705-023-2347-3
标题 作者 时间 类型 操作
Ribozyme and the mechanisms that underlie RNA catalysis
Timothy J. Wilson,Yijin Liu,David M. J. Lilley
期刊论文
Blockage of receptor-interacting protein 2 expression by small interfering RNA in murine macrophages
LIU Hongchun, CAO Zhongwei, JIN Jianjun, WANG Jiyao
期刊论文
Overexpressed long noncoding RNA CRNDE with distinct alternatively spliced isoforms in multiple cancers
Xuefei Ma, Wei Zhang, Rong Zhang, Jingming Li, Shufen Li, Yunlin Ma, Wen Jin, Kankan Wang
期刊论文
Sustainable functionalization and modification of materials via multicomponent reactions in water
期刊论文
Research progress on low dielectric constant modification of cellulose insulating paper for power transformers
期刊论文
Potential use of serum HBV RNA in antiviral therapy for chronic hepatitis B in the era of nucleos(t)ide
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期刊论文
immune escape and microenvironment between RG-like and pri-OPC-like glioma revealed by single-cell RNA-seq
期刊论文
Construction and identification of lentiviral RNA interference vector of rat leptin receptor gene
Zhengjuan LIU, Jie BIAN, Yuchuan WANG, Yongli ZHAO, Dong YAN, Xiaoxia WANG
期刊论文
Crystal modification of rifapentine using different solvents
Kun ZHOU, Jun LI, Jianhong LUO, Dongsheng ZHENG,
期刊论文